The Eyre Highway is now reopened, after a semi-trailer fire in the Nullabor yesterday.
The CFS were called to the HazMat emergency at around 11.30am, after the truck carrying household insecticides caught fire.
It was expected to continue to produce smoke for up to 24 hours, with toxic fumes impacting the surrounding area and reducing visibility and causing the road to be closed.
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The Eyre Highway between Eucla and Yalata reopened around 8pm last night.
There may still be smoke visible in the area this morning.